Genome Assembly

Hi-C data plays a crucial role in genome assembly. The 3D structure of the genome captured by the long-range chromatin interactions of Hi-C data is vital for the process of scaffolding, where smaller DNA fragments (or contigs) are connected into longer, chromosome-level scaffolds. This helps to minimize assembly errors and ensures that contigs are placed in their correct order and orientation in the resultant assembled genome.

Compatible Tools

Libraries generated by Dovetail Genomics kits, such as Omni-C and LinkPrep, are compatible with a wide range of genome assembly and scaffolding tools that utilize Hi-C data.

These include, but are not limited to, the following:

• Hifiasm

• Verkko

• YaHS

• SALSA

• AutoHiC

• DipASM

• C-Phasing

• HapHiC

• Vertebrate Genomes Project